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New research projects at Ƭ are investigating the reasons for the extinction of prehistoric shark species and developing a new method for analysis of large biomolecules using nuclear magnetic resonance spectroscopy
Two outstanding researchers at Ƭ have each successfully secured a prestigious fellowship from the European Research Council (ERC) for their pioneering research projects: Geoscientist Dr. Jeremy McCormack, within the framework of his ERC Starting Grant, is investigating to what extent the ecology of prehistoric sharks increased their risk of extinction. Chemist Dr. Andrei Kuzhelev is advancing an ultra-high-resolution nuclear magnetic resonance spectroscopy to study the dynamics of complex biomolecules in nanoliter-sized samples. The grant are each endowed with around 1.5 million euros.
FRANKFURT. Professor Enrico Schleiff, President of Ƭ, congratulated the two researchers: “The research projects of Jeremy McCormack and Andrei Kuzhelev are impressive examples of how we at Ƭ continue to push the boundaries of what can still be measured—whether it is atomic traces of sharks' diets preserved in their teeth, or an innovative spectroscopic tool for investigating the dynamics of large biomolecules. I am delighted that the European Research Council is funding these forward-looking projects."
SHARKS: In the midst of the sixth great mass extinction in Earth's history – today – geoscientist Dr. Jeremy McCormack is focusing in his ERC project on sharks, a quarter of whose species are threatened with extinction, mainly due to overfishing. Using new methods for analyzing zinc, calcium, and nitrogen isotopes in fossil teeth of various prehistoric shark species, he is investigating how the ecology and especially the diet of these predators may have contributed to their extinction. This is possible because the ratio of different isotopes within their teeth shifts depending on the level of the food chain from which a shark's prey originated. These insights are expected to shed light on the causes of extinction of prehistoric shark species and contribute to conservation strategies for today's endangered sharks.
LiquidStateDNP: In his ERC project, Dr. Andrei Kuzhelev will develop nuclear magnetic resonance (NMR) spectroscopy for biomolecule solutions at a nanoliter scale. For this, he is using a specialized NMR technique – Liquid-State Dynamic Nuclear Polarization (DNP) – available at the Biomolecular Magnetic Resonance Center (BMRZ) at Ƭ, which offers globally unique analytical possibilities: Unlike similar methods, which require shock-freezing of biomaterial samples, it allows the study of even the smallest sample quantities in liquid phase, much closer to their natural state. Kuzhelev will significantly advance this method to reveal not only the structures and dynamics of small, but also of large, complex biomolecules – a decisive technological step forward for various applications ranging from materials science to the development of medical drugs.
ERC Starting Grants support outstanding researchers in the first years after their doctorate who wish to establish their own research team and gain a foothold in the scientific community with a promising research project. For their projects, they receive up to 1.5 million euros over a period of up to five years.
The European Research Council (ERC) is a body established by the European Commission to fund frontier-oriented basic research.
Picture download:
Dr. Jeremy McCormack, Ƭ Frankfurt. Photo: Jürgen Lecher
Dr. Andrei Kuzhelev, Goethe-University Frankfurt. Photo: private
Editor: Dr. Markus Bernards, Science Editor, PR & Communications Office, Theodor-W.-Adorno-Platz 1, 60323 Frankfurt, Tel: +49 (0) 69 798-12498, bernards@em.uni-frankfurt.de